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CircSamd4 regulates Serpine1 expression by sponging miR-1894-3p. (A) The expression of miR-1894-3p is reduced in fibrotic hearts induced by TAC (n = 5). (B) The expression of miR-1894-3p is reduced in activated fibroblasts induced by TGF-β1 (n = 3). (C) Validation of miR-1894-3p overexpression in cardiac fibroblasts transfected with mimics-miR-1894-3p (n = 3). (D) miR-1894-3p overexpression decreases the protein levels of the fibrotic markers FN1, POSTN, and CTGF in TGF-β1-treated cardiac fibroblasts (n = 3). (E) The expression of miR-1894-3p in cardiac fibroblasts is upregulated by circSamd4 knockdown (n = 3). (F) Prediction of the base pairing of circSamd4 and miR-1894-3p. (G) Verification of miR-1894-3p as a sponge target of circSamd4 via <t>a</t> <t>dual-luciferase</t> reporter assay (n = 4). (H) Relative mRNA expression of Serpine1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (I) The protein expression of PAI-1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (J) Prediction of the base pairing of miR-1894-3p and the Serpine1 3′-UTR. (K) Verification of Serpine1 as a target gene of miR-1894-3p via a dual-luciferase reporter assay (n = 4). (L) circSamd4 regulates Serpine1 expression in a miR-1894-3p-depedent manner in cardiac fibroblasts (n = 3). (M) Schematic showing circSamd4 serves as a sponge of miR-1894-3p to release its suppression of Serpine1 expression in cardiac fibroblasts. ns, P > 0.05, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. Data in A, B, C, E, G, H, I and K was analyzed with Student's t -test, data in D and L was analyzed by one-way ANOVA with Bonferroni post hoc multiple comparison test.
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CircSamd4 regulates Serpine1 expression by sponging miR-1894-3p. (A) The expression of miR-1894-3p is reduced in fibrotic hearts induced by TAC (n = 5). (B) The expression of miR-1894-3p is reduced in activated fibroblasts induced by TGF-β1 (n = 3). (C) Validation of miR-1894-3p overexpression in cardiac fibroblasts transfected with mimics-miR-1894-3p (n = 3). (D) miR-1894-3p overexpression decreases the protein levels of the fibrotic markers FN1, POSTN, and CTGF in TGF-β1-treated cardiac fibroblasts (n = 3). (E) The expression of miR-1894-3p in cardiac fibroblasts is upregulated by circSamd4 knockdown (n = 3). (F) Prediction of the base pairing of circSamd4 and miR-1894-3p. (G) Verification of miR-1894-3p as a sponge target of circSamd4 via a dual-luciferase reporter assay (n = 4). (H) Relative mRNA expression of Serpine1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (I) The protein expression of PAI-1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (J) Prediction of the base pairing of miR-1894-3p and the Serpine1 3′-UTR. (K) Verification of Serpine1 as a target gene of miR-1894-3p via a dual-luciferase reporter assay (n = 4). (L) circSamd4 regulates Serpine1 expression in a miR-1894-3p-depedent manner in cardiac fibroblasts (n = 3). (M) Schematic showing circSamd4 serves as a sponge of miR-1894-3p to release its suppression of Serpine1 expression in cardiac fibroblasts. ns, P > 0.05, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. Data in A, B, C, E, G, H, I and K was analyzed with Student's t -test, data in D and L was analyzed by one-way ANOVA with Bonferroni post hoc multiple comparison test.

Journal: Redox Biology

Article Title: Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1

doi: 10.1016/j.redox.2026.104018

Figure Lengend Snippet: CircSamd4 regulates Serpine1 expression by sponging miR-1894-3p. (A) The expression of miR-1894-3p is reduced in fibrotic hearts induced by TAC (n = 5). (B) The expression of miR-1894-3p is reduced in activated fibroblasts induced by TGF-β1 (n = 3). (C) Validation of miR-1894-3p overexpression in cardiac fibroblasts transfected with mimics-miR-1894-3p (n = 3). (D) miR-1894-3p overexpression decreases the protein levels of the fibrotic markers FN1, POSTN, and CTGF in TGF-β1-treated cardiac fibroblasts (n = 3). (E) The expression of miR-1894-3p in cardiac fibroblasts is upregulated by circSamd4 knockdown (n = 3). (F) Prediction of the base pairing of circSamd4 and miR-1894-3p. (G) Verification of miR-1894-3p as a sponge target of circSamd4 via a dual-luciferase reporter assay (n = 4). (H) Relative mRNA expression of Serpine1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (I) The protein expression of PAI-1 in cardiac fibroblasts is reduced by miR-1894-3p overexpression (n = 3). (J) Prediction of the base pairing of miR-1894-3p and the Serpine1 3′-UTR. (K) Verification of Serpine1 as a target gene of miR-1894-3p via a dual-luciferase reporter assay (n = 4). (L) circSamd4 regulates Serpine1 expression in a miR-1894-3p-depedent manner in cardiac fibroblasts (n = 3). (M) Schematic showing circSamd4 serves as a sponge of miR-1894-3p to release its suppression of Serpine1 expression in cardiac fibroblasts. ns, P > 0.05, ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.001. Data in A, B, C, E, G, H, I and K was analyzed with Student's t -test, data in D and L was analyzed by one-way ANOVA with Bonferroni post hoc multiple comparison test.

Article Snippet: After-transfection, dual-luciferase activity was measured using a Dual-Luciferase Reporter Assay Kit (Vazyme, DL101-01, China) following the manufacturer's instructions.

Techniques: Expressing, Biomarker Discovery, Over Expression, Transfection, Knockdown, Luciferase, Reporter Assay, Comparison